Smad5 is required for mouse primordial germ cell development
نویسندگان
چکیده
منابع مشابه
Smad5 is required for mouse primordial germ cell development
Smad5, together with Smad1 and Smad8, have been implicated as downstream signal mediators for several bone morphogenetic proteins (BMPs). Recent studies have shown that primordial germ cells (PGCs) are absent or greatly reduced in Bmp4 or Bmp8b mutant mice. To define the role of Smad5 in PGC development, we examined PGC number in Smad5 mutant mice by Oct4 whole-mount in situ hybridization and a...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2001
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(01)00367-7